## rxode2parse - Parsing and Code Generation Functions for 'rxode2'

Provides the parsing needed for 'rxode2' (Wang, Hallow and James (2016) <doi:10.1002/psp4.12052>). It also provides the 'stan' based advan linear compartment model solutions with gradients (Carpenter et al (2015), <doi:10.48550/arXiv.1509.07164>) needed in 'nlmixr2' (Fidler et al (2019) <doi:10.1002/psp4.12445>). This split will reduce computational burden of recompiling 'rxode2'.

Last updated 12 days ago

1 stars 3.39 score 22 dependencies 15 dependents## lotri - A Simple Way to Specify Symmetric, Block Diagonal Matrices

Provides a simple mechanism to specify a symmetric block diagonal matrices (often used for covariance matrices). This is based on the domain specific language implemented in 'nlmixr2' but expanded to create matrices in R generally instead of specifying parts of matrices to estimate.

Last updated 18 days ago

4 stars 3.22 score 1 dependencies 15 dependents## nlmixr2est - Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Last updated 1 months ago

6 stars 3.44 score 69 dependencies 8 dependents## rxode2random - Random Number Generation Functions for 'rxode2'

Provides the random number generation (in parallel) needed for 'rxode2' (Wang, Hallow and James (2016) <doi:10.1002/psp4.12052>) and 'nlmixr2' (Fidler et al (2019) <doi:10.1002/psp4.12445>). This split will reduce computational burden of recompiling 'rxode2'.

Last updated 1 months ago

1 stars 3.21 score 26 dependencies 14 dependents## nlmixr2 - Nonlinear Mixed Effects Models in Population PK/PD

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Last updated 1 months ago

37 stars 3.35 score 149 dependencies 2 dependents## nlmixr2plot - Nonlinear Mixed Effects Models in Population PK/PD, Plot Functions

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>). This package is for 'ggplot2' plotting methods for 'nlmixr2' objects.

Last updated 1 months ago

2 stars 1.82 score 148 dependencies 3 dependents## nlmixr2extra - Nonlinear Mixed Effects Models in Population PK/PD, Extra Support Functions

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>). This package is for support functions like preconditioned fits <doi:10.1208/s12248-016-9866-5>, boostrap and stepwise covariate selection.

Last updated 2 months ago

3 stars 2.12 score 80 dependencies 4 dependents## babelmixr2 - Use 'nlmixr2' to Interact with Open Source and Commercial Software

Run other estimation and simulation software via the 'nlmixr2' (Fidler et al (2019) <doi:10.1002/psp4.12445>) interface including 'PKNCA', 'NONMEM' and 'Monolix'. While not required, you can get/install the 'lixoftConnectors' package in the 'Monolix' installation, as described at the following url <https://monolix.lixoft.com/monolix-api/lixoftconnectors_installation/>. When 'lixoftConnectors' is available, 'Monolix' can be run directly instead of setting up command line usage.

Last updated 2 months ago

monolixnonmempharmacometrics

5 stars 1.71 score 155 dependencies## rxode2et - Event Table Functions for 'rxode2'

Provides the event table and support functions needed for 'rxode2' (Wang, Hallow and James (2016) <doi:10.1002/psp4.12052>) and 'nlmixr2' (Fidler et al (2019) <doi:10.1002/psp4.12445>). This split will reduce computational burden of recompiling 'rxode2'.

Last updated 2 months ago

1 stars 3.12 score 29 dependencies 13 dependents## nlmixr2data - Nonlinear Mixed Effects Models in Population PK/PD, Data

Datasets for 'nlmixr2' and 'rxode2'. 'nlmixr2' is used for fitting and comparing nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Last updated 5 months ago

3 stars 2.61 score 0 dependencies 9 dependents## rxode2ll - Log-Likelihood Functions for 'rxode2'

Provides the log-likelihoods with gradients from 'stan' (Carpenter et al (2015), <arXiv:1509.07164>) needed for generalized log-likelihood estimation in 'nlmixr2' (Fidler et al (2019) <doi:10.1002/psp4.12445>). This is split of to reduce computational burden of recompiling 'rxode2' (Wang, Hallow and James (2016) <doi:10.1002/psp4.12052>) which runs the 'nlmixr2' models during estimation.

Last updated 1 years ago

2 stars 2.87 score 7 dependencies 13 dependents