nlmixr2 - Nonlinear Mixed Effects Models in Population PK/PD
Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).
Last updated 30 days ago
8.19 score 39 stars 2 packages 98 scripts 1.8k downloadsnlmixr2est - Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines
Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).
Last updated 4 hours ago
7.89 score 7 stars 8 packages 20 scripts 1.6k downloadslotri - A Simple Way to Specify Symmetric, Block Diagonal Matrices
Provides a simple mechanism to specify a symmetric block diagonal matrices (often used for covariance matrices). This is based on the domain specific language implemented in 'nlmixr2' but expanded to create matrices in R generally instead of specifying parts of matrices to estimate. It has expanded to include some matrix manipulation functions that are generally useful for 'rxode2' and 'nlmixr2'.
Last updated 1 months ago
7.72 score 5 stars 13 packages 18 scripts 2.1k downloadslbfgsb3c - Limited Memory BFGS Minimizer with Bounds on Parameters with optim() 'C' Interface
Interfacing to Nocedal et al. L-BFGS-B.3.0 (See <http://users.iems.northwestern.edu/~nocedal/lbfgsb.html>) limited memory BFGS minimizer with bounds on parameters. This is a fork of 'lbfgsb3'. This registers a 'R' compatible 'C' interface to L-BFGS-B.3.0 that uses the same function types and optimization as the optim() function (see writing 'R' extensions and source for details). This package also adds more stopping criteria as well as allowing the adjustment of more tolerances.
Last updated 1 months ago
7.55 score 15 packages 16 scripts 4.1k downloadsbabelmixr2 - Use 'nlmixr2' to Interact with Open Source and Commercial Software
Run other estimation and simulation software via the 'nlmixr2' (Fidler et al (2019) <doi:10.1002/psp4.12445>) interface including 'PKNCA', 'NONMEM' and 'Monolix'. While not required, you can get/install the 'lixoftConnectors' package in the 'Monolix' installation, as described at the following url <https://monolixsuite.slp-software.com/r-functions/2024R1/installation-and-initialization>. When 'lixoftConnectors' is available, 'Monolix' can be run directly instead of setting up command line usage.
Last updated 13 hours ago
monolixnonmempharmacometrics
6.63 score 8 stars 41 scripts 723 downloadsnlmixr2extra - Nonlinear Mixed Effects Models in Population PK/PD, Extra Support Functions
Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>). This package is for support functions like preconditioned fits <doi:10.1208/s12248-016-9866-5>, boostrap and stepwise covariate selection.
Last updated 1 months ago
5.46 score 3 stars 4 packages 10 scripts 1.6k downloadsnlmixr2data - Nonlinear Mixed Effects Models in Population PK/PD, Data
Datasets for 'nlmixr2' and 'rxode2'. 'nlmixr2' is used for fitting and comparing nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).
Last updated 9 months ago
5.08 score 3 stars 9 packages 6 scripts 1.5k downloadsnlmixr2plot - Nonlinear Mixed Effects Models in Population PK/PD, Plot Functions
Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>). This package is for 'ggplot2' plotting methods for 'nlmixr2' objects.
Last updated 1 months ago
4.80 score 2 stars 3 packages 6 scripts 1.4k downloadsrxode2ll - Log-Likelihood Functions for 'rxode2'
Provides the log-likelihoods with gradients from 'stan' (Carpenter et al (2015), <arXiv:1509.07164>) needed for generalized log-likelihood estimation in 'nlmixr2' (Fidler et al (2019) <doi:10.1002/psp4.12445>). This is split of to reduce computational burden of recompiling 'rxode2' (Wang, Hallow and James (2016) <doi:10.1002/psp4.12052>) which runs the 'nlmixr2' models during estimation.
Last updated 2 years ago
4.71 score 2 stars 12 packages 1 scripts 1.4k downloadsn1qn1 - Port of the 'Scilab' 'n1qn1' Module for Unconstrained BFGS Optimization
Provides 'Scilab' 'n1qn1'. This takes more memory than traditional L-BFGS. The n1qn1 routine is useful since it allows prespecification of a Hessian. If the Hessian is near enough the truth in optimization it can speed up the optimization problem. The algorithm is described in the 'Scilab' optimization documentation located at <https://www.scilab.org/sites/default/files/optimization_in_scilab.pdf>. This version uses manually modified code from 'f2c' to make this a C only binary.
Last updated 2 months ago
4.26 score 1 stars 9 packages 4 scripts 1.4k downloadsrxode2parse - Parsing and Code Generation Functions for 'rxode2'
Provides the parsing needed for 'rxode2' (Wang, Hallow and James (2016) <doi:10.1002/psp4.12052>). It also provides the 'stan' based advan linear compartment model solutions with gradients (Carpenter et al (2015), <doi:10.48550/arXiv.1509.07164>) needed in 'nlmixr2' (Fidler et al (2019) <doi:10.1002/psp4.12445>). This split will reduce computational burden of recompiling 'rxode2'.
Last updated 30 days ago
archivedpackagesr-universe
3.54 score 5 stars 2 packages 1 scripts 2.3k downloadsrxode2random - Random Number Generation Functions for 'rxode2'
Provides the random number generation (in parallel) needed for 'rxode2' (Wang, Hallow and James (2016) <doi:10.1002/psp4.12052>) and 'nlmixr2' (Fidler et al (2019) <doi:10.1002/psp4.12445>). This split will reduce computational burden of recompiling 'rxode2'.
Last updated 1 months ago
archivedpackagesr-universe
3.41 score 5 stars 2 packages 2 scripts 1.7k downloads